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Psychiatry General

Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish.

Feb 28, 2020

Schizophrenia is a neuropsychiatric condition that reaches around 1% of people worldwide. Because taurine exerts a neuroprotective role in the brain, this molecule is a promising candidate to reduce s...

Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior.

Feb 28, 2020

Caffeine is the most widely consumed psychoactive substance in the world. However, there is controversy about whether becoming addicted to caffeine is possible and a lack of well-established animal mo...

Trajectories and mental health-related predictors of perceived discrimination and stigma among homeless adults with mental illness.

Feb 28, 2020

Stigma and discrimination toward individuals experiencing homelessness and mental disorders remain pervasive across societies. However, there are few longitudinal studies of stigma and discrimination ...

Organization of primate amygdalar-thalamic pathways for emotions.

Feb 28, 2020

Studies on the thalamus have mostly focused on sensory relay nuclei, but the organization of pathways associated with emotions is not well understood. We addressed this issue by testing the hypothesis...

Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy.

Feb 28, 2020

Accumulation of abnormal tau aggregates in the brain is a pathological hallmark of multiple neurodegenerative disorders including Alzheimer's disease. Increasing evidence suggests that soluble tau agg...

Intestinal flora dysbiosis aggravates cognitive dysfunction associated with neuroinflammation in heart failure.

Feb 28, 2020

Cognitive dysfunction after heart failure (HF) is characterized by neuroinflammation, which plays an important role in the occurrence and development of cognitive dysfunction. Recent studies have show...

The impact of ethnicity on the clinical presentations of spinocerebellar ataxia type 3.

Feb 28, 2020

For a variety of sporadic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, it is well-established that ethnicity does affect the disease p...

Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).

Feb 28, 2020

Patients suffering from dementia experience cognitive deficits and 90% of them show non-cognitive behavioral and psychological symptoms of dementia (BPSD). The spectrum of BPSD includes agitation, dep...

Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease.

Feb 28, 2020

Alzheimer's disease (AD) is characterised by a dynamic process of neurocognitive changes from normal cognition to mild cognitive impairment (MCI) and progression to dementia. However, not all individu...

The structure of mania: An overview of factorial analysis studies.

Feb 28, 2020

Operational definitions of mania are based on expert consensus rather than empirical data. The aim of this study is to identify the key domains of mania, as well as the relevance of the different sign...

Relationship between dysfunctional beliefs, self-esteem, extreme appraisals, and symptoms of mania and depression over time in bipolar disorder.

Feb 28, 2020

Bipolar disorder (BD) is a mental health problem characterized by episodes of mania and depression which can lead to significant difficulties impairing one's daily functioning. Cross-sectional researc...

Serum testosterone levels in bipolar and unipolar depressed female patients and the role of medication status.

Feb 28, 2020

to compare testosterone levels between female depressed patients and female bipolar patients. Sixty-one female patients with major depressive disorder (MDD) ( = 23) or bipolar disorder (BD) ( =...

Science, Medicine and the Creation of a 'Healthy' Soviet Cinema.

Feb 28, 2020

Cinema had long been hailed by Bolshevik party leaders as a crucial ally of the Soviet mass enlightenment project. By the mid-1920s, however, Soviet psychologists, educators and practitioners of 'chil...

Impulsivity, Unplanned Pregnancies, and Contraception Among Women with Bipolar Disorder.

Feb 28, 2020

Impulsivity is one of the principal symptoms of bipolar and related disorders (BD). Unsafe sex and unplanned pregnancies are serious problems in clinical practice. The aim of this study was to investi...

Xenon produces rapid antidepressant- and anxiolytic-like effects in lipopolysaccharide-induced depression mice model.

Feb 28, 2020

Onset delay of current antidepressants is always the most significant limitation for the treatment of depression. More attention has been given to the glutamate acid system for developing fast-onset a...

Health-related quality of life in older Chinese patients with diabetes.

Feb 28, 2020

Although older diabetes patients with unique characteristics should be cared carefully to improve their health-related quality of life (HRQOL), the association between diabetes and HRQOL remain unclea...

The Virtual Operative Assistant: An explainable artificial intelligence tool for simulation-based training in surgery and medicine.

Feb 28, 2020

Simulation-based training is increasingly being used for assessment and training of psychomotor skills involved in medicine. The application of artificial intelligence and machine learning technologie...

An evaluation study of caregiver perceptions of the Ontario's Health Links program.

Feb 28, 2020

In 2012, the Ontario government launched Health Links (HL), which was designed to integrate care for patients with multimorbidity and complex needs who are high users of health services. This study ev...

The relationship between sensory sensitivity, food fussiness and food preferences in children with neurodevelopmental disorders.

Feb 28, 2020

Heightened sensitivity to sensory information has been associated with food fussiness in both atypical and typical development. Despite food fussiness and sensory dysfunction being reported as common ...

Evaluating the added values of regional climate modeling over China at different resolutions.

Feb 28, 2020

Previous studies have suggested that dynamical downscaling to global climate models can produce improved climate simulations at regional and local scales. However, the expensive computational requirem...

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