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Psychiatry General

Differences in clinical presentation between newly diagnosed bipolar I and II disorders: A naturalistic study.

Jan 22, 2024

This naturalistic clinical study aims to investigate differences between newly diagnosed patients with bipolar type I (BDI) and bipolar type II (BDII) disorders in socio-demographic and clinical chara...

Evaluating the development and well-being assessment (DAWBA) in pediatric anxiety and depression.

Jan 22, 2024

Enhancing screening practices and developing scalable diagnostic tools are imperative in response to the increasing prevalence of youth mental health challenges. Structured lay psychiatric interviews ...

Comorbidity of Dementia: A Cross-Sectional Study of PUMCH Dementia Cohort.

Jan 15, 2024

Comorbidities reduce quality of life for people with dementia and caregivers. Some comorbidities share a genetic basis with dementia.The objective of this study is to assess comorbidity in patients wi...

Influence of TMX2-CTNND1 polymorphism on cortical thickness in schizophrenia and their unaffected sibling: an exploratory study based on target region sequencing.

Jan 15, 2024

The advancement of neuroimaging and genetic research has revealed the presence of morphological abnormalities and numerous risk genes, along with their associations.The cortical thickness of 129 schiz...

Serum neurofilament light as a potential marker of illness duration in bipolar disorder.

Jan 15, 2024

Investigation on specific biomarkers for diagnostic or prognostic usage in mental diseases and especially bipolar disorder BD seems to be one outstanding field in current research. Serum neurofilament...

Biomarkers of bipolar disorder based on metabolomics: A systematic review.

Jan 15, 2024

Bipolar disorder (BD) is a severe affective disorder characterized by recurrent episodes of depression or mania/hypomania, which significantly impair cognitive function, life skills, and social abilit...

Comparison of brexpiprazole, aripiprazole, and placebo for Japanese major depressive disorder: A systematic review and network meta-analysis.

Jan 15, 2024

This systematic review and frequentist network meta-analysis used random-effects models is conducted to determine whether there are differences in the efficacy, acceptability, tolerability, and safety...

Enhancing drug checking services for supply monitoring: perspectives on implementation in syringe service programs in the USA.

Jan 15, 2024

Shifts in the US drug supply, including the proliferation of synthetic opioids and emergence of xylazine, have contributed to the worsening toll of the overdose epidemic. Drug checking services offer ...

A Systematic Evaluation of Machine Learning-Based Biomarkers for Major Depressive Disorder.

Jan 15, 2024

Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one of the most prevalent and disabling mental disorders, major depressive disorder...

Safety of Macitentan for the Treatment of Portopulmonary Hypertension: Real-World Evidence from the Combined OPUS/OrPHeUS Studies.

Jan 08, 2024

Portopulmonary hypertension (PoPH) carries a worse prognosis than other forms of pulmonary arterial hypertension (PAH). Data regarding use of PAH-specific therapies in patients with PoPH are sparse as...

Synergism of fermented feed and ginseng polysaccharide on growth performance, intestinal development, and immunity of Xuefeng black-bone chickens.

Jan 08, 2024

Microbial fermented feed (MF) is considered a valuable strategy to bring advantages to livestock and is widely practiced. Oral supplementation of Ginseng polysaccharide (Gps) eliminated weight loss in...

Factors Associated With Oral Anticoagulant Use in Patients With Atrial Fibrillation and Mental Disorders.

Jan 08, 2024

This study aims to identify how mental illness severity interacts with oral anticoagulant (OAC) patterns among people with atrial fibrillation (AF). AF patients with comorbid mental illness (classif...

Novel Quality Control Metric for the Pharmacotherapy of Major Depressive Disorder: Measuring Guideline Concordance and Its Impact on Symptom Severity.

Jan 08, 2024

Studies suggest that people with major depressive disorder (MDD) often receive treatment that is not concordant with practice guidelines. To evaluate this, we (1) developed a guideline concordance al...

AI-Powered Mental Health Virtual Assistants' Acceptance: An Empirical Study on Influencing Factors Among Generations X, Y, and Z.

Jan 01, 2024

This study aims to analyze various influencing factors among generations X (Gen X), Y (Gen Y), and Z (Gen Z) of artificial intelligence (AI)-powered mental health virtual assistants.A cross-sectional ...

The consumption of psychoactive substances among French physicians: how do they perceive the creation of a dedicated healthcare system?

Jan 01, 2024

Substance use among physicians can have negative impacts on their health, quality of life, and patient care. While Physician Health Programs (PHPs) have proven effective, many physicians with substanc...

Effectiveness and safety of second-generation antipsychotics for psychiatric disorders apart from schizophrenia: A systematic review and meta-analysis.

Jan 01, 2024

Second-generation antipsychotics (SGAs) are widely used in treating schizophrenia and related disorders, also other mental disorders. However, the efficacy and safety of SGAs for treating other mental...

"Trust me, do not trust anyone": how epistemic mistrust and credulity are associated with conspiracy mentality.

Jan 01, 2024

Previous research shows that the propensity to endorse conspiracy theories is associated with disrupted forms of epistemic trust, i.e., the appropriate openness towards interpersonally communicated in...

Sedative and hypnotic effects of Polygala tenuifolia willd. saponins on insomnia mice and their targets.

Dec 25, 2023

Polygala tenuifolia Willd. has been widely used in the treatment of cancer, forgetfulness, depression and other diseases.The purpose of this study was to investigate the sleep-enhancing effect and mec...

Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review.

Dec 25, 2023

While genetic and cohort studies suggest immune and reduction/oxidation (redox) alterations occur in psychosis, less is known about potential alterations in children and adolescents.We conducted a sys...

Resolving heterogeneity in schizophrenia, bipolar I disorder, and attention-deficit/hyperactivity disorder through individualized structural covariance network analysis.

Dec 25, 2023

Disruptions in large-scale brain connectivity are hypothesized to contribute to psychiatric disorders, including schizophrenia, bipolar I disorder, and attention-deficit/hyperactivity disorder. Howeve...

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