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Psychiatry General

Outcome measures for Alzheimer's disease

May 06, 2021

The main aim of this file is to study Individuals with Down condition (DS) regularly build up Alzheimer's illness (AD) neuropathology before age 40, however an absence of result measures and longitudi...

Enrichment in Alzheimer's disease

May 06, 2021

The investigation of Alzheimer's sickness (AD) has uncovered natural pathways with suggestions for illness neuropathology and pathophysiology. These pathway‐level impacts may likewise be interceded ...

Executive function composite score

May 06, 2021

The main objective of this study is to Neuropsychological test batteries directed through large‐scale, longitudinal maturing concentrates normally incorporate a few EF measures.14 This guarantees es...

Prevalence and factors associated with ulcer-related pain in persons with chronic leg ulcers-an explorative study.

May 06, 2021

The aims of this study were to explore the prevalence of background pain and identify demographic, clinical and psychosocial factors associated with moderate to severe background pain in persons with ...

Long-term changes in self-reported sleep quality and risk of chronic musculoskeletal pain: The HUNT Study.

May 06, 2021

We examined the association between long-term (~10 years) changes in self-reported sleep quality and risk of any chronic musculoskeletal pain and chronic widespread pain. The study comprised data on ...

The relationship between cannabis and schizophrenia: a genetically informed perspective.

May 06, 2021

While epidemiologic studies support a role for heavy, high-potency cannabis use on first episode psychosis, genetic models of causation suggest reverse causal effects of schizophrenia on cannabis use ...

Functionally selective and biased agonists of muscarinic receptors.

May 06, 2021

Disruption of cholinergic signalling via muscarinic receptors is associated with various pathologies, like Alzheimer's disease or schizophrenia. Selective muscarinic agonists possess therapeutic poten...

Exploring the relation between BOLD fMRI and cognitive performance using a computer-based quantitative systems pharmacology model: Applications to the COMTVAL158MET genotype and ketamine.

May 06, 2021

BOLD fMRI is increasingly used mostly in an observational way to probe the effect of genotypes or therapeutic intervention in normal and diseased subjects. We use a mechanism-based quantitative system...

Viewing personalized video clips recommended by TikTok activates default mode network and ventral tegmental area.

May 06, 2021

Cutting-edge recommendation algorithms have been widely used by media platforms to suggest users with personalized content. While such user-specific recommendations may satisfy users' needs to obtain ...

Cannabidiol prevents amphetamine relapse and modulates D1- and D2-receptor levels in mesocorticolimbic brain areas of rats.

May 06, 2021

Amphetamine (AMPH) is an addictive psychostimulant highly used worldwide and its consumption is related to neurotoxic effects. Currently, there is no pharmacotherapy approved for treating AMPH or othe...

Are Individuals with Substance Use Disorders at Higher Risk of SARS-CoV-2 Infection? Population-Based Registry Study in Northern Italy.

May 06, 2021

This study assesses whether individuals with substance use disorder are at greater risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than people in the general population....

The clinical significance of abnormal ejaculation by silodosin. Is it important?

May 06, 2021

We aimed to evaluate the effect of the abnormal ejaculation (AEj) on patients using silodosin in terms of drug cessation. We also analysed the possible factors that may affect the decisions of patient...

Efficacy and Safety of LCZ696 for Short-term Management of Essential Hypertension Compared With ARBs: A Meta-analysis of Randomized Controlled Trials.

May 06, 2021

Whether LCZ696 (neprilysin inhibitor + valsartan) has greater advantages of blood pressure (BP) lowering than angiotensin II type 1 receptor blockers (ARBs) is unclear. To provide more detailed inform...

Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item-score models.

May 06, 2021

This study tested the hypothesis that analyzing longitudinal item scores of the Unified Parkinson's Disease Rating Scale could allow a smaller trial size and describe a drug's effect on symptom progre...

Cognition-immune interactions between executive function and working memory, tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and sTNFR2) in bipolar disorder.

May 06, 2021

This study examined cognition-immune interactions, specifically executive function, working memory, peripheral levels of tumour necrosis factor-alpha (TNF-α), and soluble tumour necrosis factor recep...

Moderators of Treatment for Pediatric Bipolar Spectrum Disorders.

May 06, 2021

We review the current limited research on pediatric bipolar spectrum disorder (BPSD) treatment moderators..Four pharmacotherapy and nine psychotherapy moderator studies in youth with pediatric BPSD is...

Is unipolar mania a distinct entity: findings from the bipolar disorder course and outcome study from India (BiD-CoIN study).

May 06, 2021

This study aimed to evaluate the prevalence of unipolar mania (UM) in a group of patients of bipolar disorder (BD). Additionally, effort was made to evaluate the demographic, clinical and treatment re...

Prevalence and Risk Factors for Anxiety and Depression in Patients With COVID-19 in Wuhan, China.

May 06, 2021

Infectious diseases can cause psychological changes in patients. This study aimed to evaluate the prevalence and related risk factors for anxiety and depression in patients with COVID-19.A cross-secti...

Simultaneous determination of both kavalactones and flavokawains constituents by different single marker in Kava.

May 06, 2021

Kava, the rhizomes and roots of Piper methysticum Forst, is a popular edible medicinal herb traditionally used to prepare beverages for anxiety reduction. Since the German kava ban has been lifted by ...

Acute alcohol intoxication modulates the temporal dynamics of resting electroencephalography networks.

May 06, 2021

This study aimed to provide a currently missing link between general intoxication-induced changes in overall brain activity and the multiple cognitive control deficits typically observed during acute ...

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