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Psychiatry General

Objectively measured digital technology use during the COVID-19 pandemic: Impact on depression, anxiety, and suicidal ideation among young adults.

Apr 26, 2021

Research suggests that the disruptions introduced by the COVID-19 pandemic have led to increased psychological distress and time spent on digital technology among young people, thus intensifying pre-p...

Four year evaluation of therapeutic hysteroscopy under procedural sedation in an outpatient clinic.

Apr 26, 2021

Due to the evolution of hysteroscopic instruments, therapeutic hysteroscopic procedures are increasingly performed in an outpatient, office-based setting. The most important limiting factor of perform...

Set Shifting and Inhibition Deficits as Potential Endophenotypes for Depression.

Apr 26, 2021

The etiology of Major Depressive Disorder (MDD) is poorly understood, and identifying endophenotypes, or intermediate processes implicated in pathophysiology, for MDD may inform treatment and identifi...

Narcolepsy Treatment: Voices of Adolescents.

Apr 22, 2021

: Narcolepsy, characterized by excessive daytime sleepiness, is a debilitating lifelong sleep disorder for which there is no cure. Current pharmacological and nonpharmacological treatments directed to...

Feasibility and patient-reported satisfaction using a novel point-of-care fingerstick method for monitoring absolute neutrophil count for clozapine.

Apr 22, 2021

Clozapine is an effective antipsychotic for treatment-resistant schizophrenia. One limitation of clozapine use is required monitoring of absolute neutrophil count (ANC) because of the risk of clozapin...

Effects of Genome-Wide Neuroticism-Associated Variants on Five-Factor Model Personality Traits in Schizophrenia.

Apr 22, 2021

Patients with schizophrenia (SCZ) have characteristic personality traits compared with healthy subjects. Genome-wide significant variants for neuroticism have been reported in healthy subjects. Howeve...

Using Computational Modelling to Capture Schizophrenia-Specific Reinforcement Learning Differences and Their Implications on Patient Classification.

Apr 22, 2021

Psychiatric diagnosis and treatment have historically taken a symptom-based approach, with less attention on identifying underlying symptom-producing mechanisms. Recent efforts have illuminated the ex...

Potentiation of (α4)2(β2)3, but not (α4)3(β2)2, Nicotinic Acetylcholine Receptors Reduces Nicotine Self-Administration and Withdrawal Symptoms.

Apr 22, 2021

The low sensitivity (α4)3(β2)2 (LS) and high sensitivity (α4)2(β2)3 (HS) nAChR isoforms may contribute to a variety of brain functions, pathophysiological processes, and pharmacological effects as...

General anaesthesia in end-of-life care: extending the indications for anaesthesia beyond surgery.

Apr 22, 2021

In this article, we describe an extension of general anaesthesia - beyond facilitating surgery - to the relief of suffering during dying. Some refractory symptoms at the end of life (pain, delirium, d...

The impact of manic symptoms in first-episode psychosis: findings from the UK National EDEN study.

Apr 22, 2021

The extant literature is inconsistent over whether manic symptoms in First Episode Psychosis (FEP) impact on its development and trajectory. This study addressed: 1) Does Duration of Untreated Illness...

Docking analysis for identification of lead compound and 3d pharmacophore generation against gsk-3β involved in bipolar disorder.

Apr 22, 2021

Bipolar disorder is a psychiatric illness that strikes between mania and depression, caused by both genetic and environmental factors. It is the sixth leading cause of disability worldwide and 3% of t...

Prediction of repeated-dose intravenous ketamine response in major depressive disorder using the GWAS-based machine learning approach.

Apr 22, 2021

Major depressive disorder (MDD) is one of the most common psychiatric disorders. Various clinical studies have shown that the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has rapid, robust...

Healthcare Experiences of Individuals With Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia.

Apr 22, 2021

Persistent genital arousal disorder/genito-pelvic dysesthesia (PGAD/GPD) is a distressing condition characterized by persistent, unwanted sensations of genital arousal (eg, feelings of being on the ve...

Social factors and worry associated with COVID-19: Evidence from a large survey in China.

Apr 22, 2021

Worry about COVID-19 is an important cognitive component and manifestation of COVID-19-related anxiety. It has a social dimension and is shaped by various social factors.We employ original data from a...

Evaluation of Promega PowerSeq™ Auto/Y systems prototype on an admixed sample of Rio de Janeiro, Brazil: Population data, sensitivity, stutter and mixture studies.

Apr 22, 2021

Forensic DNA typing typically relies on the length-based (LB) separation of PCR products containing short tandem repeat loci (STRs). Massively parallel sequencing (MPS) elucidates an additional level ...

The Association Between Psoriasis & Vascular Dementia

Apr 20, 2021

“Psoriasis has been linked with a variety of systemic disorders, including cardiovascular (CV) conditions, which may predispose patients to developing dementia,” explains Megan Lam, BSc. “While ...

SARS-CoV-2-associated first episode of acute mania with psychotic features.

Apr 19, 2021

Despite neuropsychiatric outcomes of SARS-CoV-2 infection are now under close scrutiny, psychoneuroimmunological characteristics of COVID-19 and precise pathophysiology of neuropsychiatric manifestati...

Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.

Apr 19, 2021

Narcolepsy type 1 (NT1) is a chronic neurological disorder having a strong association with HLA-DQB1*0602, thereby suggesting an immunological origin. Increased risk of NT1 has been reported among chi...

Which of Us were More Affected by the Pandemic? The Psychiatric Impacts of the COVID-19 Pandemic on Healthcare Professionals in the Province Where the First Quarantine Units were Established in Turkey.

Apr 19, 2021

Psychiatric problems, such as stress and anxiety disorders, are encountered among healthcare professionals fighting epidemics. Considering that COVID-19 suddenly became a pandemic and healthcare profe...

Impaired error-related processing in patients with first-episode psychosis and subjects at clinical high risk for psychosis: An event-related potential study.

Apr 19, 2021

Impaired event-related potential (ERP) indices reflecting performance monitoring systems have been consistently reported in patients with schizophrenia. However, whether these impairments exist from t...

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