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Psychiatry General

Response to targeted cognitive training may be neuroprotective in patients with early schizophrenia.

Apr 19, 2021

Individuals with schizophrenia exhibit widespread cortical thinning associated with illness severity and deficits in cognition. However, intact cortical thickness (CTh) may serve as a protective facto...

Disentangling Cognitive Heterogeneity in Psychotic Spectrum Disorders.

Apr 19, 2021

Neuropsychological impairments represent a central feature of psychosis-spectrum disorders. It is characterized by a great both within- and between-subjects variability (i.e. cognitive heterogeneity),...

Safety of surgical fertility preservation procedures in children prior to Hematopoietic Stem Cell Transplant.

Apr 19, 2021

Long-term survival following hematopoietic stem cell transplant (HSCT) in childhood continues to improve and patients are thus increasingly faced with the late effects of treatment. Infertility is ver...

Prediction of minimum postmortem submersion interval (PMSI) based on eukaryotic community succession on skeletal remains recovered from a lentic environment.

Apr 19, 2021

Although recent studies explored using microbial succession during decomposition to estimate the postmortem interval (PMI) and postmortem submersion interval (PMSI), there is currently no published re...

Citrate ligand-enhanced microscale zero-valent aluminum corrosion for carbon tetrachloride degradation with high electron utilization efficiency.

Apr 19, 2021

Carbon tetrachloride (CT) is highly toxic and recalcitrant in groundwater. In recent years, zero-valent aluminum (ZVAl) is highly reductive but limited by its surface passivation film. One of the effe...

Type 1 narcolepsy without cataplexy and treatment progress: a case report.

Apr 15, 2021

Narcolepsy is a sleep disorder with the main manifestations of excessive daytime sleepiness, cataplexy, sleep paralysis, sleep hallucinations, and nighttime sleep disturbance. It is still not fully re...

The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.

Apr 15, 2021

Accumulation of senile plaques mainly composed of neurotoxic amyloid-beta peptide (Aβ) is a pathological hallmark of Alzheimer's disease (AD). Sestrin2 inducible by various types of stressors is know...

Self-Adjustment of Deep Brain Stimulation Delays Optimization in Parkinson's disease.

Apr 15, 2021

Parkinson's Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery.To assess whether the use of the advanced functions of a patient's...

Simultaneous modeling of Alzheimer's disease progression via multiple cognitive scales.

Apr 15, 2021

Analyzing the progression of Alzheimer's disease (AD) is challenging due to lacking sensitivity in currently available measures. AD stages are typically defined based on cognitive cut-offs, but this r...

Abnormal Large-Scale Network Activation Present in Bipolar Mania and Bipolar Depression Under Resting State.

Apr 15, 2021

Previous studies have primarily focused on the neuropathological mechanisms of the emotional circuit present in bipolar mania and bipolar depression. Recent studies applying resting-state functional ...

HIV Post Exposure Prophylaxis and Risk of Relapse in Adolescent With Bipolar Illness and Psychopharmacologic Challenges.

Apr 15, 2021

Bipolar disorder (BD) in adolescents is associated with risky behaviors, including high risk for sexually transmitted infections. When exposed, post exposure prophylaxis (PEP) is recommended within 7...

Lupus Cerebritis Refractory to Guideline-Directed Therapy: A Case Report.

Apr 15, 2021

Systemic lupus erythematosus is an autoimmune disease that affects multiple organs and organ systems, subsequently requiring an elaborate regimen for management. We present the case of a 63-year-old f...

T cell reactivity to regulatory factor X4 in type 1 narcolepsy.

Apr 12, 2021

Type 1 narcolepsy is strongly (98%) associated with human leukocyte antigen (HLA) class II DQA1*01:02/DQB1*06:02 (DQ0602) and highly associated with T cell receptor (TCR) alpha locus polymorphism as w...

Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder.

Apr 12, 2021

Deficits in brain morphology are one of the most widely replicated neuropathological features in schizophrenia-spectrum disorder (SSD), although their biological underpinnings remain unclear. Despite ...

The role of depression in the prediction of a "late" remission in first-episode psychosis: An analysis of the OPTiMiSE study.

Apr 12, 2021

The identification of predictors of psychosis remission could guide early clinical decision-making for treatment of first-episode schizophrenia (FES).We analyzed two non-independent subsamples of pati...

Worse for girls?: Gender differences in discrimination as a predictor of suicidality among Latinx youth.

Apr 12, 2021

Gender and ethnic differences exist in suicidal ideation, plan, and attempt among adolescents in the U.S. However, limited research has used theoretically-informed approaches to integrate how cultural...

Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs.

Apr 12, 2021

Mood disorders (depression, bipolar disorders) are prevalent and disabling. They are also highly co-morbid with other psychiatric disorders. Currently there are no objective measures, such as blood te...

Measuring Mania-like Elevated Mood through Amphetamine-induced 50-kHz Ultrasonic Vocalizations in Rats.

Apr 12, 2021

Rats emit 50-kHz ultrasonic vocalizations (USV) in appetitive situations, reflecting a positive affective state. Particularly high rates of 50-kHz USV are elicited by the psychostimulant d-amphetamine...

Cognitive correlates of impulsive aggression in youth with pediatric bipolar disorder and bipolar offspring.

Apr 12, 2021

Youth with bipolar disorder (BD) and offspring of individuals with BD (BD-OFF) are characterized by higher levels of impulsive and overt aggression. The cognitive basis underlying these aggressive beh...

Development of a behavioural measure of Intolerance of Uncertainty in preadolescent children: Adaptation of the beads task.

Apr 12, 2021

Intolerance of Uncertainty (IU) may be important for the development and maintenance of anxiety disorders but research with preadolescent children has relied entirely on questionnaire measures to asse...

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