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Psychiatry General

Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders.

Apr 01, 2021

Affective disorders (AD, including bipolar disorder, BD, and major depressive disorder) are severe recurrent illnesses. Identifying neural markers of processes underlying AD development in at-risk you...

A quantitative method for the selective 5-HT2A agonist 25CN-NBOH in rat plasma and brain.

Apr 01, 2021

In recent years, agonists of the 5-HT receptor have gained increasing attention for their potential therapeutic use to treat psychological disorders such as anxiety and depression. Here, we report the...

Brain reactivity to humorous films is affected by insomnia.

Mar 29, 2021

Emotional reactivity to negative stimuli has been investigated in insomnia, but little is known about emotional reactivity to positive stimuli and its neural representation.We used 3T fMRI to determin...

Treatment-resistant schizophrenia - A RCT on the effectiveness of repeated-dose sodium nitroprusside.

Mar 29, 2021

Sodium nitroprusside (SNP) has shown efficacy in schizophrenia in early stages of the disease in a previous study, but in more recent studies it has not shown efficacy in patients with longer disease ...

[Adverse Drug Reactions in Geriatric Psychiatric Patients - Influence of Potentially Inappropriate Drugs].

Mar 29, 2021

The purpose of this study was to examine the extent to which "potentially inappropriate drugs" (PID) are associated with an increased risk for adverse drug reactions (ADR).Data from 304 geriatric psyc...

[How do Migrant Women with Depression Experience Access to Care in Germany? A Qualitative Interview Study on Difficulties and Wishes of those Affected].

Mar 29, 2021

The aim of the study was to find out how migrant women experience access to care for depression, what difficulties they have and what improvements they want.Content analysis of twelve partially struct...

Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell Safety in Idiopathic Parkinson's Disease.

Mar 29, 2021

Neuroinflammation plays a key role in PD pathogenesis, and allogeneic bone marrow-derived mesenchymal stem cells can be used as an immunomodulatory therapy.The objective of this study was to prove the...

P-MRS of the healthy human brain at 7 T detects multiple hexose derivatives of uridine diphosphate glucose.

Mar 29, 2021

Nucleotide sugars are required for the synthesis of glycoproteins and glycolipids, which play crucial roles in many cellular functions such as cell communication and immune responses. Uridine diphosph...

Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach.

Mar 29, 2021

Sphingolipids (SLs) are bioactive lipids involved in various important physiological functions. The SL pathway has been shown to be affected in several brain-related disorders, including Alzheimer's d...

Psychological complications of Cushing's syndrome.

Mar 29, 2021

The aim of this review is to review and discuss recent evidence of psychological complications in Cushing's syndrome.Recent research has described the presence of depression, anxiety, posttraumatic st...

Personality disorder among youth with first episode psychotic mania: An important target for specific treatment?

Mar 29, 2021

Personality disorder is a common co-occurrence ('comorbidity') among patients with bipolar disorder and appears to affect outcome negatively. However, there is little knowledge about the impact of thi...

Young adults with epilepsy: Relationships between psychosocial variables and anxiety, depression, and suicidality.

Mar 29, 2021

People with epilepsy (PWE) are at an increased risk of anxiety, depression, and suicidality. Young adulthood is a critical developmental period which can be complicated by the unique challenges of hav...

#PWChat: The Status of Mental Healthcare in The US

Mar 26, 2021

The latest installment of the #PWChat series centered around the status of mental healthcare in the United States. Below are the highlights from the chat. You can read the full transcript here, b...

The functional significance of cognitive empathy and theory of mind in early and chronic schizophrenia.

Mar 25, 2021

Theoretical models suggest that it is the interplay between social cognitive processes that result in adaptive social functioning in schizophrenia. This study explored the relative contributions of, a...

CDC's Efforts to Quantify Prescription Opioid Overdose Deaths Fall Short.

Mar 25, 2021

In a 2018 report titled, Quantifying the Epidemic of Prescription Opioid Overdose Deaths, four senior analysts of the Centers for Disease Control and Prevention (CDC), including the head of the Epidem...

Associations between Reason for Inpatient Palliative Care Consultation, Timing, and Cost Savings.

Mar 25, 2021

Specialty palliative care (SPC) provides patient-centered care to people with serious illness and may reduce costs. Specific cost-saving functions of SPC remain unclear. (1) To assess the effect of ...

Cognitive Predictors of Social and Occupational Functioning in Early Psychosis: A Systematic Review and Meta-analysis of Cross-Sectional and Longitudinal Data.

Mar 25, 2021

Many individuals with early psychosis experience impairments in social and occupational function. Identification of modifiable predictors of function such as cognitive performance has the potential to...

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration.

Mar 25, 2021

Here, we examine the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein (αSYN) species in astrocytes derived from induced pluripotent stem cells. Human a...

Pragmatic abilities in early Parkinson's disease.

Mar 25, 2021

Language impairment in Parkinson's disease (PD) has been investigated at different levels of linguistic skills. Only a few studies dealt with pragmatic abilities in PD, and these suggest an impairment...

Automated assessment of the substantia nigra on susceptibility map-weighted imaging using deep convolutional neural networks for diagnosis of Idiopathic Parkinson's disease.

Mar 25, 2021

Despite its use in determining nigrostriatal degeneration, the lack of a consistent interpretation of nigrosome 1 susceptibility map-weighted imaging (SMwI) limits its generalized applicability. To im...

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