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Psychiatry General

Borderline personality disorder features and their relationship with trauma and dissociation in a sample of community health service users.

Jul 03, 2023

Previous studies have indicated that borderline personality disorder (BPD) is closely associated with trauma and dissociation. Nevertheless, BPD is a heterogeneous condition, and not all people with B...

Applying the Project ECHO Model to Support Implementation and Sustainment of Cognitive Behavioral Therapy for Psychosis.

Jul 03, 2023

Project Extension for Community Healthcare Outcomes (ECHO) is a teleconsultation model that leverages technology to sustain specialized interventions in underresourced settings. We present the applica...

Relationship between stress and resident non-technical skills during interdisciplinary trauma simulations.

Jul 03, 2023

Non-technical skills, such as communication and situation awareness, are vital for patient care and effective surgical team performance. Previous research has found that residents' perceived stress is...

Relationship between stress and resident non-technical skills during interdisciplinary trauma simulations.

Jul 03, 2023

Non-technical skills, such as communication and situation awareness, are vital for patient care and effective surgical team performance. Previous research has found that residents' perceived stress is...

Antidepressant effects of novel positive allosteric modulators of Trk-receptor mediated signaling - a potential therapeutic concept?

Jul 03, 2023

Major depressive disorder (MDD) is defined as a complex mental disorder which is characterized by a pervasive low mood and aversion to activity. Several types of neurotransmitter systems e.g. serotone...

Antidepressant effects of novel positive allosteric modulators of Trk-receptor mediated signaling - a potential therapeutic concept?

Jul 03, 2023

Major depressive disorder (MDD) is defined as a complex mental disorder which is characterized by a pervasive low mood and aversion to activity. Several types of neurotransmitter systems e.g. serotone...

Analysis of metabolic syndrome and cognitive functional analysis in schizophrenic patients based on psychological intervention.

Jun 26, 2023

In this paper, we explore the characteristics of cognitive dysfunction in patients with schizophrenia complicated with metabolic syndrome (MS), and to explore the effects of psychological intervention...

Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids.

Jun 26, 2023

De novo mutations and copy number deletions in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). It is unclear how NRXN1 deletions impact cortical development in a cell type-specific man...

Long-term course of cognitive functioning in bipolar disorder: A ten-year follow-up study.

Jun 26, 2023

Cognitive impairments are common in bipolar disorder (BD), but the long-term course remains understudied. Longitudinal data on cognitive functioning from the start of the first treatment could help cl...

Method comparison and estimation of causal effects of insomnia on health outcomes in a survey sampled population.

Jun 19, 2023

Applying causal inference methods, such as weighting and matching methods, to a survey sampled population requires properly incorporating the survey weights and design to obtain effect estimates that ...

BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?

Jun 19, 2023

Alzheimer's disease is a neurodegenerative disease mainly characterized by cortico-neuronal atrophy, impaired memory and other cognitive declines. On the other hand, schizophrenia is a neuro-developme...

Lessons learned from the translation of the Internalised Stigma of Mental Illness (ISMI) scale into isiXhosa for use with South African Xhosa people with schizophrenia.

Jun 19, 2023

Internalised stigma is highly prevalent among people with mental illness. This is concerning because internalised stigma is often associated with negative consequences affecting individuals' personal,...

Tracing the Roots of Dementia Praecox: Charles Lasègue and his 1852 Essay "Du Délire De Persécutions" (On Persecutory Delusions).

Jun 19, 2023

While the evolution of our modern concepts of mania and melancholia over the 19th century is relatively well-understood, no such clear narrative exists for the nonaffective psychotic syndromes that cu...

Comparison of NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) as inflammatory markers in 1 episode mania and bipolar mania: A preliminary study.

Jun 19, 2023

There are various factors including inflammation that have been studied in bipolar disorder. NLR (Neutrophil to lymphocyte ratio) and PLR (platelet to lymphocyte ratio) are one of them. Various psycho...

Is burning mouth syndrome associated with stress? A meta-analysis.

Jun 19, 2023

Some studies have shown Burning Mouth Syndrome (BMS) as comorbid psychosocial and psychiatric disorders, and as well, pointed at stress as a major risk factor.The aim of this meta-analysis was to answ...

Clinical Promise of Brain-Phenotype Modeling: A Review.

Jun 19, 2023

Assessing the link between whole-brain activity and individual differences in cognition and behavior has the potential to offer insights into psychiatric disorder etiology and change the practice of p...

Sleep in Gerstmann-Straüssler-Scheinker disease.

Jun 12, 2023

Gerstmann-Sträussler-Scheinker (GSS) is a rare prion disease with heterogeneous clinical presentation. Although sleep-related abnormalities are prominent and well-known in other prion diseases such a...

Focused Ultrasound Stimulates the Prefrontal Cortex and Prevents MK-801-Induced Psychiatric Symptoms of Schizophrenia in Rats.

Jun 12, 2023

Treatment of schizophrenia remains a major challenge. Recent studies have focused on glutamatergic signaling hypoactivity through N-methyl-D-aspartate (NMDA) receptors. Low-intensity pulsed ultrasound...

Epigenomic analysis of Alzheimer's disease brains reveals diminished CTCF binding on genes involved in synaptic organization.

Jun 12, 2023

Epigenetic aberrations are suggested to play an important role in transcriptional alterations in Alzheimer's disease (AD). One of the key mechanisms of epigenetic regulation of gene expression is thro...

Tau positron emission tomography in patients with cognitive impairment and suspected Alzheimer's disease.

Jun 12, 2023

Alzheimer's disease (AD) is diagnosed by the presence of both amyloid β and tau proteins. Recent advances in molecular PET imaging have made it possible to assess the accumulation of these proteins i...

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