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Psychiatry General

Chronic Mania: Diagnostic Dilemma and the Need for Addition in Nosology.

Jun 12, 2023

Chronic mania is a mental health disorder that has been described by various psychiatrists in the past but currently is not a part of nosology. Robust epidemiological data for chronic mania are lackin...

Challenges and opportunities for improvement when people with an intellectual disability or serious mental illness also need palliative care: A qualitative meta-ethnography.

Jun 12, 2023

People with diagnoses of intellectual disability or serious mental illness have higher mortality rates due to physical comorbidities; better understanding is needed to guide best practice in provision...

Air pollution and attention in Polish schoolchildren with and without ADHD.

Jun 12, 2023

Development and functioning of attention-a key component of human cognition-can be affected by environmental factors. We investigated whether long- and short-term exposure to particulate matter with a...

Sex hormones, insomnia, and sleep quality: Subjective sleep in the first year of hormone use in transgender persons.

Jun 05, 2023

Transgender persons can use gender-affirming hormone therapy (GAHT) to align their physical appearance with their identified gender. Many transgender persons report poor sleep, but the effects of GAHT...

The effects of group-based cognitive behavioral therapy in the rehabilitation of patients with chronic schizophrenia with more than two years of community-based mental health group rehabilitation.

Jun 05, 2023

Studies have shown that community-based group rehabilitation activities can have a positive impact on patients.This study attempted to improve schizophrenia patients' social and self-cognition through...

CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance.

Jun 05, 2023

The hypothesis of dopamine dysfunction in psychosis has evolved since the mid-twentieth century. However, clinical support from biochemical analysis of the transmitter in patients is still missing. Th...

"How sad it is! I shall grow old, and horrible, and dreadful" - the ups and downs of cell senescence.

Jun 05, 2023

This issue of the Biomedical Journal contains a special section about cell senescence. The reader gets an insight into the crosstalk between immune system and senescent cells, into an approach to figh...

Dynamic time warp analysis of individual symptom trajectories in individuals with bipolar disorder.

Jun 05, 2023

Manic and depressive mood states in bipolar disorder (BD) may emerge from the non-linear relations between constantly changing mood symptoms exhibited as a complex dynamic system. Dynamic Time Warp (D...

A pilot pharmacogenetic study of calcium channel blocker treatment of bipolar mania.

Jun 05, 2023

Common genetic variants located in calcium channel genes are important markers of genetic susceptibility for bipolar disorder (BD). Previous clinical trials with Calcium Channel Blocker (CCB) medicati...

Efficacy of transcutaneous electrical acupoint stimulation for patients with first-episode schizophrenia: An 8-week, preliminary, randomized controlled trial.

May 29, 2023

Combination therapy with antipsychotics has been investigated for treating schizophrenia, and has shown clear advantages among non-invasive therapies. Transcutaneous electrical acupoint stimulation (T...

Longer Hospitalizations, More Complications, and Greater Readmissions for Patients with Comorbid Psychiatric Disorders Undergoing Pulmonary Lobectomy.

May 29, 2023

To examine the impact of comorbid psychiatric disorders on postoperative outcomes in pulmonary lobectomy patients.A retrospective analysis of the Healthcare Cost and Utilization Project Nationwide Rea...

The efficacy and safety of lurasidone in bipolar I depression with and without rapid cycling: A pooled post-hoc analysis of two randomized, placebo-controlled trials.

May 29, 2023

The efficacy and safety of lurasidone monotherapy in patients with bipolar I depression with or without rapid cycling has not been previously investigated.We performed subgroup analysis (rapid cycling...

A multicenter, double-blind, placebo-controlled, randomized, Phase 1b crossover trial comparing two doses of ulotaront with placebo in the treatment of narcolepsy-cataplexy.

May 22, 2023

Ulotaront (SEP-363856) is a novel agonist at trace amine-associated receptor 1 and serotonin 5-HT receptors in clinical development for the treatment of schizophrenia. Previous studies demonstrated ul...

Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model.

May 22, 2023

Narcolepsy type 1 (NT1) is a neurological disorder caused by disruption of hypocretin (HCRT; or orexin) neurotransmission leading to fragmented sleep/wake states, excessive daytime sleepiness (EDS), a...

Relation between white matter integrity, perfusion, and processing speed in early-stage schizophrenia.

May 22, 2023

Cerebral blood flow (CBF) plays a critical role in the maintenance of neuronal integrity, and CBF alterations have been linked to deleterious white matter changes. Several studies report CBF and white...

A clinical risk prediction tool for identifying the risk of violent offending in severe mental illness: A retrospective case-control study.

May 22, 2023

Individuals with severe mental illness are at a higher risk of violence than the general population. However, there is a lack of available and simple tools to screen for the risk of violent offending ...

Promoting research engagement among women with addiction: Impact of recovery peer support in a pilot randomized mixed-methods study.

May 22, 2023

The impact of involving peers on research engagement is largely unknown. The purpose of this pilot study, a part of a larger research, was to evaluate the impact of recovery peer involvement as a stud...

Dapagliflozin inhibits the activity of lateral habenula to alleviate diabetes mellitus-induced depressive-like behavior.

May 22, 2023

The prevalence of depression in diabetes mellitus (DM) patients is very high, and it severely impacts the prognosis and quality of life of these patients. Sodium-glucose co-transporter 2 (SGLT2) inhib...

Factors associated with objective and subjective cognitive impairment in Chinese patients with acute major depressive disorder.

May 22, 2023

Patients diagnosed withmajor depressive disorder (MDD) usually experience impaired cognitive functioning, which might negatively impact their clinical and functional outcomes. This study aimed to inve...

The role of NMDA receptors in bipolar disorder: A systematic review.

May 22, 2023

Glutamatergic transmission and N-methyl-D-aspartate receptors (NMDARs) have been implicated in the pathophysiology schizophrenic spectrum and major depressive disorders. Less is known about the role o...

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